Type: Article

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration: advancing biosynthetic gene cluster curation through global collaboration

Zdouc, Mitja M. Blin, Kai Louwen, Nico L. L. Navarro, Jorge Loureiro, Catarina Bader, Chantal D. Bailey, Constance B. Barra, Lena Booth, Thomas J. Bozhüyük, Kenan A. J. Cediel-Becerra, José D. D. Charlop-Powers, Zachary Chevrette, Marc G. Chooi, Yit Heng DAgostino, Paul M. de Rond, Tristan Pup, Elena Del Duncan, Katherine R. Gu, Wenjia Hanif, Novriyandi Helfrich, Eric J. N. Jenner, Matthew Katsuyama, Yohei Korenskaia, Aleksandra Krug, Daniel Libis, Vincent Lund, George A. Mantri, Shrikant Morgan, Kalindi D. Owen, Charlotte Phan, Chin-Soon Philmus, Benjamin Reitz, Zachary L. Robinson, Serina L. Singh, Kumar Saurabh Teufel, Robin Tong, Yaojun Tugizimana, Fidele Ulanova, Dana Winter, Jaclyn M. Aguilar, César Akiyama, Daniel Y. Al-Salihi, Suhad A. A. Alanjary, Mohammad Alberti, Fabrizio Aleti, Gajender Alharthi, Shumukh A. Arias Rojo, Mariela Y. Arishi, Amr A. Augustijn, Hannah E. Avalon, Nicole E. Avelar-Rivas, J. Abraham Axt, Kyle K. Barbieri, Hellen B. Barbosa, Julio Cesar J. Segato, Lucas Gabriel Barboza Barrett, Susanna E. Baunach, Martin Beemelmanns, Christine Beqaj, Dardan Berger, Tim Bernaldo-Agüero, Jordan Bettenbühl, Sandra M. Bielinski, Vincent A. Biermann, Friederike Borges, Ricardo M. Borriss, Rainer Breitenbach, Milena Bretscher, Kevin M. Brigham, Michael W. Buedenbender, Larissa Bulcock, Brodie W. Cano-Prieto, Carolina Ribeiro, João Manuel Capela Araújo Carrion, Victor J. Carter, Riley S. Castelo-Branco, Raquel Castro-Falcón, Gabriel Chagas, Fernanda O. Charria-Girón, Esteban Chaudhri, Ayesha Ahmed Chaudhry, Vasvi Choi, Hyukjae Choi, Yukyung Choupannejad, Roya Chromy, Jakub Chue Donahey, Melinda S. Collemare, Jérôme Connolly, Jack A. Creamer, Kaitlin E. Crüsemann, Max Cruz, Andres Arredondo Cumsille, Andres Dallery, Jean-Felix Damas-Ramos, Luis Caleb Damiani, Tito de Kruijff, Martinus Martín, Belén Delgado Sala, Gerardo Della Dillen, Jelle Doering, Drew T. Dommaraju, Shravan R. Durusu, Suhan Egbert, Susan Ellerhorst, Mark Faussurier, Baptiste Fetter, Artem Feuermann, Marc Fewer, David P. Foldi, Jonathan Frediansyah, Andri Garza, Erin A. Gavriilidou, Athina Gentile, Andrea Gerke, Jennifer Gerstmans, Hans Gomez-Escribano, Juan Pablo González-Salazar, Luz A. Grayson, Natalie E. Greco, Claudio Gris Gomez, Juan E. Guerra, Sebastian Flores, Shaday Guerrero Gurevich, Alexey Gutiérrez-García, Karina Hart, Lauren Haslinger, Kristina He, Beibei Hebra, Teo Hemmann, Jethro L. Hindra, Hindra Höing, Lars Holland, Darren C. Holme, Jonathan E. Horch, Therese Hrab, Pavlo Hu, Jie Huynh, Thanh-Hau Hwang, Ji-Yeon Iacovelli, Riccardo Iftime, Dumitrita Iorio, Marianna Jayach ran, Sidharth Jeong, Eunah Jing, Jiayi Jung, Jung J. Kakumu, Yuya Kalkreuter, Edward Kang, Kyo Bin Kang, Sangwook Kim, Wonyong Kim, Geum Jin Kim, Hyunwoo Kim, Hyun Uk Klapper, Martin Koetsier, Robert A. Kollten, Cassandra Kovács, Ákos T. Kriukova, Yelyzaveta Kubach, Noel Kunjapur, Aditya M. Kushnareva, Aleksandra K. Kust, Andreja Lamber, Jessica Larralde, Martin Larsen, Niels J. Launay, Adrien P. Le, Ngoc-Thao-Hien Lebeer, Sarah Lee, Byung Tae Lee, Kyungha Lev, Katherine L. Li, Shu-Ming Li, Yong-Xin Licona-Cassani, Cuauhtémoc Lien, Annette Liu, Jing Lopez, Julius Adam V. Machushynets, Nataliia V. Macias, Marla I. Mahmud, Taifo Maleckis, Matiss Martinez-Martinez, Añadir Maharai Mast, Yvonne Maximo, Marina F. McBride, Christina M. McLellan, Rose M. Bhatt, Khyati Mehta Melkonian, Chrats Merrild, Aske Metsä-Ketelä, Mikko Mitchell, Douglas A. Müller, Alison V. Nguyen, Giang-Son Nguyen, Hera T. Niedermeyer, Timo H. J. OHare, Julia H. Ossowicki, Adam Ostash, Bohdan O. Otani, Hiroshi Padva, Leo Paliyal, Sunaina Pan, Xinya Panghal, Mohit Parade, Dana S. Park, Jiyoon Parra, Jonathan Rubio, Marcos Pedraza Pham, Huong T. Pidot, Sacha J. Piel, Jörn Pourmohsenin, Bita Rakhmanov, Malik Ramesh, Sangeetha Rasmussen, Michelle H. Rego, Adriana Reher, Raphael Rice, Andrew J. Rigolet, Augustin Romero-Otero, Adriana Rosas-Becerra, Luis Rodrigo Rosiles, Pablo Y. Rutz, Adriano Ryu, Byeol Sahadeo, Libby-Ann Saldanha, Murrel Salvi, Luca Sánchez-Carvajal, Eduardo Santos-Medellin, Christian Sbaraini, Nicolau Schoellhorn, Sydney M. Schumm, Clemens Sehnal, Ludek Selem, Nelly Shah, Anjali D. Shishido, Tania K. Sieber, Simon Silviani, Velina Singh, Garima Singh, Hemant Sokolova, Nika Sonnenschein, Eva C. Sosio, Margherita Sowa, Sven T. Steffen, Karin Stegmann, Evi Streiff, Alena B. Strüder, Alena Surup, Frank Svenningsen, Tiziana Sweeney, Douglas Szenei, Judit Tagirdzhanov, Azat Tan, Bin Tarnowski, Matthew J. Terlouw, Barbara R. Rey, Thomas Thome, Nicola U. Ortega, Laura Rosina Torres Tørring, Thomas Trindade, Marla Truman, Andrew W. Tvilum, Marie Udwary, Daniel W. Ulbricht, Christoph Vader, Lisa van Wezel, Gilles P. Walmsley, Max Warnasinghe, Randika Weddeling, Heiner G. Weir, Angus N. M. Williams, Katherine Williams, Sam E. Witte, Thomas E. Wood Rocca, Steffaney M. Yamada, Keith Yang, Dong Yang, Dongsoo Yu, Jingwei Zhou, Zhenyi Ziemert, Nadine Zimmer, Lukas Zimmermann, Alina Zimmermann, Christian van der Hooft, Justin J. J. Linington, Roger G. Weber, Tilmann Medema, Marnix H.;

Abstract:

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.