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Type: Article
FuNTB: a functional network clustering tool for the analysis of genome-wide genetic variants in Mycobacterium tuberculosis
Ramos-García, Axel, A.; Mejía-Ponce, Paulina, M.; Nelly Sélem-Mojica, Nelly; Santos-Díaz, Alejandro; Martínez-Ledesma,; Emmanuel; Licona-Cassani, Cuauhtémoc;
Abstract:
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), still claims around 1.25 million lives each year. The growing threat of drug resistance—often driven by single-nucleotide polymorphisms (SNPs) in Mtb genomes underscores the need for high-quality genomic data and powerful bioinformatics tools. We present FuNTB, a python-based pipeline that detects non-synonymous SNPs in Mtb and builds functional network clusters to reveal genotype–phenotype relationships.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), still claims around 1.25 million lives each year. The growing threat of drug resistance—often driven by single-nucleotide polymorphisms (SNPs) in Mtb genomes underscores the need for high-quality genomic data and powerful bioinformatics tools. We present FuNTB, a python-based pipeline that detects non-synonymous SNPs in Mtb and builds functional network clusters to reveal genotype–phenotype relationships.
Journal: Bioinformatics
ISSN: 1367-4811
Year: 2025
Volume: 41
Number: 7
Pages: btaf341
Revision: 1
Notas: CC BY Scimago 2025: Q1 This work was supported by Tecnológico de Monterrey and Consejo Nacional de Humanidades Ciencia y Tecnología (CONAHCYT) CVU No. 965752. C.L.C. received financial support from CONAHCYT through Frontera Grant No. FOP16-2021-01-319590. We thank Industrial Genomics Laboratory at FEMSA Biotechnology Center and StrainBiotech for financial support.
Created: 2025-08-01 14:03:09
Modified: 2025-08-01 14:03:44
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