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Centro de Ciencias Matemáticas UNAM

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FuNTB: a functional network clustering tool for the analysis of genome-wide genetic variants in Mycobacterium tuberculosis

Abstract:

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), still claims around 1.25 million lives each year. The growing threat of drug resistance—often driven by single-nucleotide polymorphisms (SNPs) in Mtb genomes underscores the need for high-quality genomic data and powerful bioinformatics tools. We present FuNTB, a python-based pipeline that detects non-synonymous SNPs in Mtb and builds functional network clusters to reveal genotype–phenotype relationships.
Journal: Bioinformatics
ISSN: 1367-4811
Year: 2025
Volume: 41
Number: 7
Pages: btaf341
Revision: 1
Notas: CC BY Scimago 2025: Q1 This work was supported by Tecnológico de Monterrey and Consejo Nacional de Humanidades Ciencia y Tecnología (CONAHCYT) CVU No. 965752. C.L.C. received financial support from CONAHCYT through Frontera Grant No. FOP16-2021-01-319590. We thank Industrial Genomics Laboratory at FEMSA Biotechnology Center and StrainBiotech for financial support.
Created Created: 2025-08-01 14:03:09
Modified Modified: 2025-08-01 14:03:44
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